Tumor-targeted nanoparticle delivery of HuR siRNA inhibits lung tumor growth in vitro and in vivo by disrupting the oncogenic activity of the RNA-binding protein HuR

Selective downregulation of the human antigen R (HuR) protein by siRNA may provide a powerful approach for treating lung cancer. To this end, we investigated the efficacy of transferrin receptor-targeted liposomal nanoparticle-based HuR siRNA (HuR-TfNP) therapy and compared to control siRNA (C)-TfNP...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Muralidharan, Ranganayaki, Babu, Anish, Amreddy, Narsireddy, Srivastava, Akhil, Chen, Allshine, Zhao, Yan Daniel, Kompella, Uday B, Munshi, Anupama, Ramesh, Rajagopal
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544587/
https://ncbi.nlm.nih.gov/pubmed/28572169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0134
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