Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells

Caffeine, generally known as a stimulant of gastric acid secretion (GAS), is a bitter-tasting compound that activates several taste type 2 bitter receptors (TAS2Rs). TAS2Rs are expressed in the mouth and in several extraoral sites, e.g., in the gastrointestinal tract, in which their functional role...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Liszt, Kathrin Ingrid, Ley, Jakob Peter, Lieder, Barbara, Behrens, Maik, Stöger, Verena, Reiner, Angelika, Hochkogler, Christina Maria, Köck, Elke, Marchiori, Alessandro, Hans, Joachim, Widder, Sabine, Krammer, Gerhard, Sanger, Gareth John, Somoza, Mark Manuel, Meyerhof, Wolfgang, Somoza, Veronika
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544304/
https://ncbi.nlm.nih.gov/pubmed/28696284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1703728114
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