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Evolution of the p53-MDM2 pathway

BACKGROUND: The p53 signalling pathway, which controls cell fate, has been extensively studied due to its prominent role in tumor development. The pathway includes the tumor supressor protein p53, its vertebrate paralogs p63 and p73, and their negative regulators MDM2 and MDM4. The p53/p63/p73-MDM s...

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Detalhes bibliográficos
Publicado no:BMC Evol Biol
Main Authors: Åberg, Emma, Saccoccia, Fulvio, Grabherr, Manfred, Ore, Wai Ying Josefin, Jemth, Per, Hultqvist, Greta
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543598/
https://ncbi.nlm.nih.gov/pubmed/28774266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12862-017-1023-y
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