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CTLA‐4 expressed by FOXP3(+) regulatory T cells prevents inflammatory tissue attack and not T‐cell priming in arthritis

Cytotoxic T‐lymphocyte antigen 4 (CTLA‐4) ‐mediated regulation of already tolerized autoreactive T cells is critical for understanding autoimmune responses. Although defects in CTLA‐4 contribute to abnormal FOXP3(+) regulatory T (Treg) cell function in rheumatoid arthritis, its role in autoreactive...

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Bibliografski detalji
Izdano u:Immunology
Glavni autori: Klocke, Katrin, Holmdahl, Rikard, Wing, Kajsa
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543501/
https://ncbi.nlm.nih.gov/pubmed/28497863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12754
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