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Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A(1) receptor

Caffeine is believed to act by blocking adenosine A(1) and A(2A) receptors (A(1)R, A(2A)R), indicating that some A(1) receptors are tonically activated. We generated mice with a targeted disruption of the second coding exon of the A(1)R (A(1)R(−/−)). These animals bred and gained weight normally and...

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Sábháilte in:
Foilsithe in:Proc Natl Acad Sci U S A
Príomhchruthaitheoirí: Johansson, Björn, Halldner, Linda, Dunwiddie, Thomas V., Masino, Susan A., Poelchen, Wolfgang, Giménez-Llort, Lydia, Escorihuela, Rosa M., Fernández-Teruel, Alberto, Wiesenfeld-Hallin, Zsuzsanna, Xu, Xiao-Jun, Hårdemark, Anna, Betsholtz, Christer, Herlenius, Eric, Fredholm, Bertil B.
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: National Academy of Sciences 2001
Ábhair:
Biological Sciences
Rochtain ar líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55434/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11470917/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.161292398
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