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Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A(1) receptor

Caffeine is believed to act by blocking adenosine A(1) and A(2A) receptors (A(1)R, A(2A)R), indicating that some A(1) receptors are tonically activated. We generated mice with a targeted disruption of the second coding exon of the A(1)R (A(1)R(−/−)). These animals bred and gained weight normally and...

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Bibliografiska uppgifter
Huvudupphovsmän: Johansson, Björn, Halldner, Linda, Dunwiddie, Thomas V., Masino, Susan A., Poelchen, Wolfgang, Giménez-Llort, Lydia, Escorihuela, Rosa M., Fernández-Teruel, Alberto, Wiesenfeld-Hallin, Zsuzsanna, Xu, Xiao-Jun, Hårdemark, Anna, Betsholtz, Christer, Herlenius, Eric, Fredholm, Bertil B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 2001
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC55434/
https://ncbi.nlm.nih.gov/pubmed/11470917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.161292398
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