Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A(1) receptor

Caffeine is believed to act by blocking adenosine A(1) and A(2A) receptors (A(1)R, A(2A)R), indicating that some A(1) receptors are tonically activated. We generated mice with a targeted disruption of the second coding exon of the A(1)R (A(1)R(−/−)). These animals bred and gained weight normally and...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Johansson, Björn, Halldner, Linda, Dunwiddie, Thomas V., Masino, Susan A., Poelchen, Wolfgang, Giménez-Llort, Lydia, Escorihuela, Rosa M., Fernández-Teruel, Alberto, Wiesenfeld-Hallin, Zsuzsanna, Xu, Xiao-Jun, Hårdemark, Anna, Betsholtz, Christer, Herlenius, Eric, Fredholm, Bertil B.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55434/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11470917/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.161292398
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