Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A(1) receptor

Caffeine is believed to act by blocking adenosine A(1) and A(2A) receptors (A(1)R, A(2A)R), indicating that some A(1) receptors are tonically activated. We generated mice with a targeted disruption of the second coding exon of the A(1)R (A(1)R(−/−)). These animals bred and gained weight normally and...

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Autors principals: Johansson, Björn, Halldner, Linda, Dunwiddie, Thomas V., Masino, Susan A., Poelchen, Wolfgang, Giménez-Llort, Lydia, Escorihuela, Rosa M., Fernández-Teruel, Alberto, Wiesenfeld-Hallin, Zsuzsanna, Xu, Xiao-Jun, Hårdemark, Anna, Betsholtz, Christer, Herlenius, Eric, Fredholm, Bertil B.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC55434/
https://ncbi.nlm.nih.gov/pubmed/11470917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.161292398
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