Balance of Anti-CD123 Chimeric Antigen Receptor Binding Affinity and Density for the Targeting of Acute Myeloid Leukemia

Chimeric antigen receptor (CAR)-redirected T lymphocytes are a promising immunotherapeutic approach and object of pre-clinical evaluation for the treatment of acute myeloid leukemia (AML). We developed a CAR against CD123, overexpressed on AML blasts and leukemic stem cells. However, potential recog...

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Vydáno v:Mol Ther
Hlavní autoři: Arcangeli, Silvia, Rotiroti, Maria Caterina, Bardelli, Marco, Simonelli, Luca, Magnani, Chiara Francesca, Biondi, Andrea, Biagi, Ettore, Tettamanti, Sarah, Varani, Luca
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542631/
https://ncbi.nlm.nih.gov/pubmed/28479045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.04.017
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