Inhibition of dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway

Dipeptidyl peptidase 4 inhibitors are used worldwide in the management of diabetes, but their role in the prevention or treatment of cardiovascular disorders has yet to be defined. We found that linagliptin, a DPP-4 inhibitor, suppressed capillary rarefaction in the hearts of mice with dietary obesi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Suda, Masayoshi, Shimizu, Ippei, Yoshida, Yohko, Hayashi, Yuka, Ikegami, Ryutaro, Katsuumi, Goro, Wakasugi, Takayuki, Yoshida, Yutaka, Okuda, Shujiro, Soga, Tomoyoshi, Minamino, Tohru
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542565/
https://ncbi.nlm.nih.gov/pubmed/28771625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182422
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