ADCC responses and blocking of EGFR-mediated signaling and cell growth by combining the anti-EGFR antibodies imgatuzumab and cetuximab in NSCLC cells

Imgatuzumab is a novel glycoengineered anti-epidermal growth factor receptor (EGFR) monoclonal antibody optimized to induce both antibody-dependent cellular cytotoxicity (ADCC) and EGFR signal transduction inhibition. We investigated anti-EGFR monoclonal antibodies imgatuzumab and cetuximab–induced...

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Udgivet i:Oncotarget
Main Authors: Kol, Arjan, van Scheltinga, Anton Terwisscha, Pool, Martin, Gerdes, Christian, de Vries, Elisabeth, de Jong, Steven
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542198/
https://ncbi.nlm.nih.gov/pubmed/28467975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17139
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