Consistency of BRCA1 and BRCA2 Variant Classifications Among Clinical Diagnostic Laboratories

PURPOSE: Genetic tests of cancer predisposition genes, BRCA1 and BRCA2, inform significant clinical decisions for both physicians and patients. Most uncovered variants are benign, and determining which few are pathogenic—disease causing—is sometimes challenging and can potentially be inconsistent am...

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Bibliografiske detaljer
Udgivet i:JCO Precis Oncol
Main Authors: Lincoln, Stephen E., Yang, Shan, Cline, Melissa S., Kobayashi, Yuya, Zhang, Can, Topper, Scott, Haussler, David, Paten, Benedict, Nussbaum, Robert L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Clinical Oncology 2017
Fag:
Original Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542009/
https://ncbi.nlm.nih.gov/pubmed/28782058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.16.00020
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