Consistency of BRCA1 and BRCA2 Variant Classifications Among Clinical Diagnostic Laboratories

PURPOSE: Genetic tests of cancer predisposition genes, BRCA1 and BRCA2, inform significant clinical decisions for both physicians and patients. Most uncovered variants are benign, and determining which few are pathogenic—disease causing—is sometimes challenging and can potentially be inconsistent am...

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Detalhes bibliográficos
Publicado no:JCO Precis Oncol
Main Authors: Lincoln, Stephen E., Yang, Shan, Cline, Melissa S., Kobayashi, Yuya, Zhang, Can, Topper, Scott, Haussler, David, Paten, Benedict, Nussbaum, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2017
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542009/
https://ncbi.nlm.nih.gov/pubmed/28782058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.16.00020
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