Targeted activation of the SHP-1/PP2A signaling axis elicits apoptosis of chronic lymphocytic leukemia cells

Lyn, a member of the Src family of kinases, is a key factor in the dysregulation of survival and apoptotic pathways of malignant B cells in chronic lymphocytic leukemia. One of the effects of Lyn’s action is spatial and functional segregation of the tyrosine phosphatase SHP-1 into two pools, one ben...

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Udgivet i:Haematologica
Main Authors: Tibaldi, Elena, Pagano, Mario Angelo, Frezzato, Federica, Trimarco, Valentina, Facco, Monica, Zagotto, Giuseppe, Ribaudo, Giovanni, Pavan, Valeria, Bordin, Luciana, Visentin, Andrea, Zonta, Francesca, Semenzato, Gianpietro, Brunati, Anna Maria, Trentin, Livio
Format: Artigo
Sprog:Inglês
Udgivet: Ferrata Storti Foundation 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541874/
https://ncbi.nlm.nih.gov/pubmed/28619847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.155747
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