Association of Altered Collagen Content and Lysyl Oxidase Expression in Degenerative Mitral Valve Disease

BACKGROUND: Collagen cross-linking is mediated by lysyl oxidase (LOX) enzyme in the extracellular matrix (ECM) of mitral valve leaflets. Alterations in collagen content and LOX protein expression in the ECM of degenerative mitral valve may enhance leaflet expansion and disease severity. METHODS: Twe...

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Detalhes bibliográficos
Publicado no:Cardiovasc Pathol
Main Authors: Purushothaman, K-Raman, Purushothaman, Meerarani, Turnbull, Irene C., Adams, David H., Anyanwu, Anelechi, Krishnan, Prakash, Kini, Annapoorna, Sharma, Samin K., O’Connor, William N, Moreno, Pedro R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541772/
https://ncbi.nlm.nih.gov/pubmed/28453968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.carpath.2017.04.001
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