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Total Synthesis of (+)-Pancratistatin by the Rh(III)-Catalyzed Addition of a Densely Functionalized Benzamide to a Sugar-Derived Nitroalkene

Herein, we report the concise total synthesis of (+)-pancratistatin, accessed in a 10 step linear sequence from commercially available inputs. The convergent synthesis features a highly diastereoselective Rh(III)-catalyzed C-H bond addition to a D-glucose derived nitroalkene and a late stage intramo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Org Lett
Prif Awduron: Potter, Tyler J., Ellman, Jonathan A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541686/
https://ncbi.nlm.nih.gov/pubmed/28537406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.7b01220
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