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Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism

No adeno-associated virus (AAV) capsid has been described in the literature to exhibit a primary oligodendrocyte tropism when a constitutive promoter drives gene expression, which is a significant barrier for efficient in vivo oligodendrocyte gene transfer. The vast majority of AAV vectors, such as...

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Bibliographische Detailangaben
Veröffentlicht in:Gene Ther
Hauptverfasser: Powell, SK, Khan, N, Parker, CL, Samulski, RJ, Matsushima, G, Gray, SJ, McCown, TJ
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541369/
https://ncbi.nlm.nih.gov/pubmed/27628693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2016.62
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