Bcl-2 enhances Ca(2+) signaling to support the intrinsic regenerative capacity of CNS axons

At a certain point in development, axons in the mammalian CNS undergo a profound loss of intrinsic growth capacity, which leads to poor regeneration after injury. Overexpression of Bcl-2 prevents this loss, but the molecular basis of this effect remains unclear. Here, we report that Bcl-2 supports a...

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Bibliografiske detaljer
Main Authors: Jiao, Jianwei, Huang, Xizhong, Feit-Leithman, Rachel Ann, Neve, Rachael Lee, Snider, William, Dartt, Darlene Ann, Chen, Dong Feng
Format: Artigo
Sprog:Inglês
Udgivet: 2005
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC554135/
https://ncbi.nlm.nih.gov/pubmed/15719013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600589
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