Selective rab11 transport and the intrinsic regenerative ability of CNS axons

Neurons lose intrinsic axon regenerative ability with maturation, but the mechanism remains unclear. Using an in-vitro laser axotomy model, we show a progressive decline in the ability of cut CNS axons to form a new growth cone and then elongate. Failure of regeneration was associated with increased...

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Pubblicato in:eLife
Autori principali: Koseki, Hiroaki, Donegá, Matteo, Lam, Brian YH, Petrova, Veselina, van Erp, Susan, Yeo, Giles SH, Kwok, Jessica CF, ffrench-Constant, Charles, Eva, Richard, Fawcett, James W
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2017
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5779230/
https://ncbi.nlm.nih.gov/pubmed/28829741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26956
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