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Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration
ClC-7 is a chloride channel of late endosomes and lysosomes. In osteoclasts, it may cooperate with H(+)-ATPases in acidifying the resorption lacuna. In mice and man, loss of ClC-7 or the H(+)-ATPase a3 subunit causes osteopetrosis, a disease characterized by defective bone resorption. We show that C...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC554126/ https://ncbi.nlm.nih.gov/pubmed/15706348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600576 |
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