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Performance and in-house validation of a bioassay for the determination of beta1-autoantibodies found in patients with cardiomyopathy

BACKGROUND: Autoantibodies specific for the adrenergic beta1-receptor were identified to be an essential factor for the pathogenesis of dilated cardiomyopathy. For the detection of these autoantibodies, a bioassay was developed and has been used, measuring the positive chronotropic effect on spontan...

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Publicat a:Heliyon
Autors principals: Wenzel, Katrin, Schulze-Rothe, Sarah, Haberland, Annekathrin, Müller, Johannes, Wallukat, Gerd, Davideit, Hanna
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541141/
https://ncbi.nlm.nih.gov/pubmed/28795160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2017.e00362
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