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L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxin
BACKGROUND: Autotaxin (ATX, NPP-2), originally purified as a potent tumor cell motility factor, is now known to be the long-sought plasma lysophospholipase D (LPLD). The integrity of the enzymatic active site, including three crucial histidine moieties, is required for motility stimulation, as well...
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Main Authors: | , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
BioMed Central
2005
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC554093/ https://ncbi.nlm.nih.gov/pubmed/15737239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-511X-4-5 |
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