Novel point mutations attenuate autotaxin activity

BACKGROUND: The secreted enzyme autotaxin (ATX) stimulates tumor cell migration, tumorigenesis, angiogenesis, and metastasis. ATX hydrolyzes nucleotides, but its hydrolysis of lysophospholipids to produce lysophosphatidic acid (LPA) accounts for its biological activities. ATX has been identified onl...

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Detalhes bibliográficos
Main Authors: Koh, Eunjin, Bandle, Russell W, Roberts, David D, Stracke, Mary L, Clair, Timothy
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649126/
https://ncbi.nlm.nih.gov/pubmed/19222837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-511X-8-4
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