Phospholipase Cγ Activation Drives Increased Production of Autotaxin in Endothelial Cells and Lysophosphatidic Acid-Dependent Regression

We previously reported that vascular endothelial growth factor (VEGF)-dependent activation of phospholipase Cγ1 (PLCγ) regulated tube stability by competing with phosphoinositide 3-kinase (PI3K) for their common substrate. Here we describe an additional mechanism by which PLCγ promoted regression of...

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Main Authors: Im, Eunok, Motiejunaite, Ruta, Aranda, Jorge, Park, Eun Young, Federico, Lorenzo, Kim, Tae-im, Clair, Timothy, Stracke, Mary L., Smyth, Susan, Kazlauskas, Andrius
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863716/
https://ncbi.nlm.nih.gov/pubmed/20231358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01275-09
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