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Femtogram Level Sensitivity achieved by Surface Engineered Silica Nanoparticles in the Early Detection of HIV Infection

We have engineered streptavidin labelled Europium doped fluorescent silica nanoparticles which significantly increased sensitivity without compromising the specificity of the immunoassay. As a proof of concept, a time resolved fluorescence based sandwich immunoassay was developed to detect HIV-1 p24...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chunduri, L. A. Avinash, Kurdekar, Aditya, Haleyurgirisetty, Mohan Kumar, Bulagonda, Eswarappa Pradeep, Kamisetti, Venkataramaniah, Hewlett, Indira K.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540927/
https://ncbi.nlm.nih.gov/pubmed/28769052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07299-1
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