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Role of Rac1 pathway in epithelial-to-mesenchymal transition and cancer stem-like cell phenotypes in gastric adenocarcinoma

Rac1, a Rho GTPase family member, is dysregulated in a variety of tumor types including gastric adenocarcinoma (GA), but little is known about its role in cancer stem-like cells (CSCs). Therefore, Rac1 activity and inhibition were examined in GA cells and mouse xenograft models for epithelial-to-mes...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Yoon, Changhwan, Cho, Soo-Jeong, Chang, Kevin K., Park, Do Joong, Ryeom, Sandra W., Yoon, Sam S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540756/
https://ncbi.nlm.nih.gov/pubmed/28461325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0053
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