Synergistic immunostimulatory effects and therapeutic benefit of combined histone deacetylase and bromodomain inhibition in non-small cell lung cancer

Effective therapies for non-small cell lung cancer (NSCLC) remain challenging despite an increasingly comprehensive understanding of somatically altered oncogenic pathways. It is now clear that therapeutic agents with potential to impact the tumor immune microenvironment potentiate immune-orchestrat...

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Publicado en:Cancer Discov
Autores principales: Adeegbe, Dennis O., Liu, Yan, Lizotte, Patrick H., Kamihara, Yusuke, Aref, Amir R., Almonte, Christina, Dries, Ruben, Li, Yuyang, Liu, Shengwu, Wang, Xiaoen, Warner-Hatten, Tiquella, Castrillon, Jessica, Yuan, Guo-Cheng, Poudel-Neupane, Neermala, Zhang, Haikuo, Guerriero, Jennifer L., Han, Shiwei, Awad, Mark M., Barbie, David A., Ritz, Jerome, Jones, Simon S., Hammerman, Peter S., Bradner, James, Quayle, Steven N., Wong, Kwok-Kin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540748/
https://ncbi.nlm.nih.gov/pubmed/28408401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-1020
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