BET bromodomain inhibition as a novel strategy for reactivation of HIV-1

The persistence of latent HIV-1 remains a major challenge in therapeutic efforts to eradicate infection. We report the capacity for HIV reactivation by a selective small molecule inhibitor of BET family bromodomains, JQ1, a promising therapeutic agent with antioncogenic properties. JQ1 reactivated H...

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Detalhes bibliográficos
Main Authors: Banerjee, Camellia, Archin, Nancie, Michaels, Daniel, Belkina, Anna C., Denis, Gerald V., Bradner, James, Sebastiani, Paola, Margolis, David M., Montano, Monty
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2012
Assuntos:
Spotlight on Leading Edge Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501896/
https://ncbi.nlm.nih.gov/pubmed/22802445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0312165
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