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Mismatch repair deficient hematopoietic stem cells are preleukemic stem cells

Whereas transformation events in hematopoietic malignancies may occur at different developmental stages, the initial mutation originates in hematopoietic stem cells (HSCs), creating a preleukemic stem cell (PLSC). Subsequent mutations at either stem cell or progenitor cell levels transform the PLSC...

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Pubblicato in:PLoS One
Autori principali: Qing, Yulan, Gerson, Stanton L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540588/
https://ncbi.nlm.nih.gov/pubmed/28767666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182175
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