Iron addiction: A novel therapeutic target in ovarian cancer

Ovarian cancer is a lethal malignancy that has not seen a major therapeutic advance in over 30 years. We demonstrate that ovarian cancer exhibits a targetable alteration in iron metabolism. Ferroportin (FPN), the iron efflux pump, is decreased, and transferrin receptor (TFR1), the iron importer, is...

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Vydáno v:Oncogene
Hlavní autoři: Basuli, Debargha, Tesfay, Lia, Deng, Zhiyong, Paul, Bibbin, Yamamoto, Yusuke, Ning, Gang, Xian, Wa, McKeon, Frank, Lynch, Miranda, Crum, Christopher P., Hegde, Poornima, Brewer, Molly, Wang, Xiaohong, Miller, Lance D., Dyment, Nathaniel, Torti, Frank M., Torti, Suzy V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540148/
https://ncbi.nlm.nih.gov/pubmed/28319068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.11
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