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Characterization of a novel modification of a CHO-produced mAb: Evidence for the presence of tyrosine sulfation
Herein we describe the investigation of a Chinese hamster ovary (CHO)-expressed human mAb molecule found partially modified by a +80 Da adduct. This mass difference, suggestive of a single sulfation or phosphorylation addition, was observed by mass analysis of the intact and reduced molecule by mass...
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| 出版年: | MAbs |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Taylor & Francis
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5540082/ https://ncbi.nlm.nih.gov/pubmed/28590151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1332552 |
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