Characterization of a novel modification of a CHO-produced mAb: Evidence for the presence of tyrosine sulfation

Herein we describe the investigation of a Chinese hamster ovary (CHO)-expressed human mAb molecule found partially modified by a +80 Da adduct. This mass difference, suggestive of a single sulfation or phosphorylation addition, was observed by mass analysis of the intact and reduced molecule by mass...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Zhao, Jia, Saunders, Jason, Schussler, Svetlana Dukleska, Rios, Sandra, Insaidoo, Francis Kobina, Fridman, Aleksandr L., Li, Huijuan, Liu, Yan-Hui
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540082/
https://ncbi.nlm.nih.gov/pubmed/28590151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1332552
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados