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Inflammation-induced GluA1 trafficking and membrane insertion of Ca(2+) permeable AMPA receptors in dorsal horn neurons is dependent on spinal tumor necrosis factor, PI3 kinase and protein kinase A

Peripheral inflammation induces sensitization of nociceptive spinal cord neurons. Both spinal tumor necrosis factor (TNF) and neuronal membrane insertion of Ca(2+) permeable AMPA receptor (AMPAr) contribute to spinal sensitization and resultant pain behavior, molecular mechanisms connecting these tw...

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Detalhes bibliográficos
Publicado no:Exp Neurol
Main Authors: Wigerblad, G., Huie, J.R., Yin, H.Z., Leinders, M., Pritchard, R.A., Koehrn, F.J., Xiao, W.-H., Bennett, G.J., Huganir, R.L., Ferguson, A.R., Weiss, J. H., Svensson, C.I., Sorkin, L.S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539914/
https://ncbi.nlm.nih.gov/pubmed/28412220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2017.04.004
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