Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection

Dengue virus (DENV) regulates sphingosine kinase (SK)-1 activity and chemical inhibition of SK1 reduces DENV infection. In primary murine embryonic fibroblasts (pMEFs) lacking SK1 however, DENV infection is enhanced and this is associated with induction of normal levels of interferon beta (IFN-β) bu...

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Vydáno v:Clin Transl Immunology
Hlavní autoři: Aloia, Amanda L, Calvert, Julie K, Clarke, Jennifer N, Davies, Lorena T, Helbig, Karla J, Pitson, Stuart M, Carr, Jillian M
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539417/
https://ncbi.nlm.nih.gov/pubmed/28791126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cti.2017.32
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