Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection

Dengue virus (DENV) regulates sphingosine kinase (SK)-1 activity and chemical inhibition of SK1 reduces DENV infection. In primary murine embryonic fibroblasts (pMEFs) lacking SK1 however, DENV infection is enhanced and this is associated with induction of normal levels of interferon beta (IFN-β) bu...

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Detalhes bibliográficos
Publicado no:Clin Transl Immunology
Main Authors: Aloia, Amanda L, Calvert, Julie K, Clarke, Jennifer N, Davies, Lorena T, Helbig, Karla J, Pitson, Stuart M, Carr, Jillian M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539417/
https://ncbi.nlm.nih.gov/pubmed/28791126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cti.2017.32
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