Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection

Dengue virus (DENV) regulates sphingosine kinase (SK)-1 activity and chemical inhibition of SK1 reduces DENV infection. In primary murine embryonic fibroblasts (pMEFs) lacking SK1 however, DENV infection is enhanced and this is associated with induction of normal levels of interferon beta (IFN-β) bu...

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Enregistré dans:
Détails bibliographiques
Publié dans:Clin Transl Immunology
Auteurs principaux: Aloia, Amanda L, Calvert, Julie K, Clarke, Jennifer N, Davies, Lorena T, Helbig, Karla J, Pitson, Stuart M, Carr, Jillian M
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
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Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539417/
https://ncbi.nlm.nih.gov/pubmed/28791126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cti.2017.32
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