Radiolabeling optimization and characterization of (68)Ga labeled DOTA–polyamido-amine dendrimer conjugate – Animal biodistribution and PET imaging results

The present study describes the optimization of (68)Ga radiolabeling with PAMAM dendrimer–DOTA conjugate. A conjugate (PAMAM–DOTA) concentration of 11.69 µM, provided best radiolabeling efficiency of more than 93.0% at pH 4.0, incubation time of 30.0 min and reaction temperature ranging between 90 a...

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Detalhes bibliográficos
Publicado no:Appl Radiat Isot
Main Authors: Ghai, Aanchal, Singh, Baljinder, Hazari, Puja Panwar, Schultz, Michael K., Parmar, Ambika, Kumar, Pardeep, Sharma, Sarika, Dhawan, Devinder, Mishra, Anil Kumar
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538890/
https://ncbi.nlm.nih.gov/pubmed/26232562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apradiso.2015.07.021
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