Preclinical Evaluation of a Potential GSH Ester Based PET/SPECT Imaging Probe DT(GSHMe)(2) to Detect Gamma Glutamyl Transferase Over Expressing Tumors

Gamma Glutamyl Transferase (GGT) is an important biomarker in malignant cancers. The redox processes ensuing from GGT-mediated metabolism of extracellular GSH are implicated in critical aspects of tumor cell biology. Reportedly, Glutathione monoethyl ester (GSHMe) is a substrate of GGT, which has be...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Khurana, Harleen, Meena, Virendra Kumar, Prakash, Surbhi, Chuttani, Krishna, Chadha, Nidhi, Jaswal, Ambika, Dhawan, Devinder Kumar, Mishra, Anil Kumar, Hazari, Puja Panwar
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4519333/
https://ncbi.nlm.nih.gov/pubmed/26221728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134281
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