Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation

The Suv39h1 and Suv39h2 histone lysine methyltransferases are hallmark enzymes at mammalian heterochromatin. We show here that the mouse Suv39h2 enzyme differs from Suv39h1 by containing an N-terminal basic domain that facilitates retention at mitotic chromatin and provides an additional affinity fo...

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Veröffentlicht in:eLife
Hauptverfasser: Velazquez Camacho, Oscar, Galan, Carmen, Swist-Rosowska, Kalina, Ching, Reagan, Gamalinda, Michael, Karabiber, Fethullah, De La Rosa-Velazquez, Inti, Engist, Bettina, Koschorz, Birgit, Shukeir, Nicholas, Onishi-Seebacher, Megumi, van de Nobelen, Suzanne, Jenuwein, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2017
Schlagworte:
Genes and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538826/
https://ncbi.nlm.nih.gov/pubmed/28760199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25293
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