Complete loss of H3K9 methylation dissolves mouse heterochromatin organization

Histone H3 lysine 9 (H3K9) methylation is a central epigenetic modification that defines heterochromatin from unicellular to multicellular organisms. In mammalian cells, H3K9 methylation can be catalyzed by at least six distinct SET domain enzymes: Suv39h1/Suv39h2, Eset1/Eset2 and G9a/Glp. We used m...

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Publicat a:Nat Commun
Autors principals: Montavon, Thomas, Shukeir, Nicholas, Erikson, Galina, Engist, Bettina, Onishi-Seebacher, Megumi, Ryan, Devon, Musa, Yaarub, Mittler, Gerhard, Meyer, Alexandra Graff, Genoud, Christel, Jenuwein, Thomas
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285382/
https://ncbi.nlm.nih.gov/pubmed/34272378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24532-8
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