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Deconstruction of the Ras switching cycle through saturation mutagenesis
Ras proteins are highly conserved signaling molecules that exhibit regulated, nucleotide-dependent switching between active and inactive states. The high conservation of Ras requires mechanistic explanation, especially given the general mutational tolerance of proteins. Here, we use deep mutational...
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| 發表在: | eLife |
|---|---|
| Main Authors: | , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
eLife Sciences Publications, Ltd
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5538825/ https://ncbi.nlm.nih.gov/pubmed/28686159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27810 |
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