Deconstruction of the Ras switching cycle through saturation mutagenesis

Ras proteins are highly conserved signaling molecules that exhibit regulated, nucleotide-dependent switching between active and inactive states. The high conservation of Ras requires mechanistic explanation, especially given the general mutational tolerance of proteins. Here, we use deep mutational...

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Библиографические подробности
Опубликовано в: :eLife
Главные авторы: Bandaru, Pradeep, Shah, Neel H, Bhattacharyya, Moitrayee, Barton, John P, Kondo, Yasushi, Cofsky, Joshua C, Gee, Christine L, Chakraborty, Arup K, Kortemme, Tanja, Ranganathan, Rama, Kuriyan, John
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2017
Предметы:
Biophysics and Structural Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538825/
https://ncbi.nlm.nih.gov/pubmed/28686159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27810
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