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Cxcr2 signaling and the microbiome suppress inflammation, bile duct injury, and the phenotype of experimental biliary atresia

Biliary atresia is progressive fibro-inflammatory cholangiopathy of young children. Central to pathogenic mechanisms of injury is the tissue targeting by the innate and adaptive immune cells. Among these cells, neutrophils and the IL-8/Cxcl-8 signaling via its Cxcr2 receptor have been linked to bile...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Jee, Junbae, Mourya, Reena, Shivakumar, Pranavkumar, Fei, Lin, Wagner, Michael, Bezerra, Jorge A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538677/
https://ncbi.nlm.nih.gov/pubmed/28763485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182089
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