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Perforin and granzymes work in synergy to mediate cholangiocyte injury in experimental biliary atresia
BACKGROUND AND AIMS: Biliary atresia represents obstructive cholangiopathy in infants progressing rapidly to cirrhosis and end-stage liver disease. Activated NK cells expressing Nkg2d have been linked to bile duct injury and obstruction by establishing contact with cholangiocytes. To define the mech...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3946990/ https://ncbi.nlm.nih.gov/pubmed/24096050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2013.09.021 |
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