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Perforin and granzymes work in synergy to mediate cholangiocyte injury in experimental biliary atresia

BACKGROUND AND AIMS: Biliary atresia represents obstructive cholangiopathy in infants progressing rapidly to cirrhosis and end-stage liver disease. Activated NK cells expressing Nkg2d have been linked to bile duct injury and obstruction by establishing contact with cholangiocytes. To define the mech...

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Main Authors: Shivakumar, Pranavkumar, Mourya, Reena, Bezerra, Jorge A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946990/
https://ncbi.nlm.nih.gov/pubmed/24096050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2013.09.021
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