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CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclib

Cyclin D‐CDK4/6 are the first CDK complexes to be activated in the G1 phase in response to oncogenic pathways. The specific CDK4/6 inhibitor PD0332991 (palbociclib) was recently approved by the FDA and EMA for treatment of advanced ER‐positive breast tumors. Unfortunately, no reliable predictive too...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:EMBO Mol Med
Κύριοι συγγραφείς: Raspé, Eric, Coulonval, Katia, Pita, Jaime M, Paternot, Sabine, Rothé, Françoise, Twyffels, Laure, Brohée, Sylvain, Craciun, Ligia, Larsimont, Denis, Kruys, Véronique, Sandras, Flavienne, Salmon, Isabelle, Van Laere, Steven, Piccart, Martine, Ignatiadis, Michail, Sotiriou, Christos, Roger, Pierre P
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: John Wiley and Sons Inc. 2017
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538335/
https://ncbi.nlm.nih.gov/pubmed/28566333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201607084
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