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CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclib
Cyclin D‐CDK4/6 are the first CDK complexes to be activated in the G1 phase in response to oncogenic pathways. The specific CDK4/6 inhibitor PD0332991 (palbociclib) was recently approved by the FDA and EMA for treatment of advanced ER‐positive breast tumors. Unfortunately, no reliable predictive too...
Αποθηκεύτηκε σε:
Τόπος έκδοσης: | EMBO Mol Med |
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Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , |
Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
John Wiley and Sons Inc.
2017
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5538335/ https://ncbi.nlm.nih.gov/pubmed/28566333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201607084 |
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