JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21

Cyclin D-CDK4/6 are the first cyclin-dependent kinase (CDK) complexes to be activated by mitogenic/oncogenic pathways. They have a central role in the cell multiplication decision and in its deregulation in cancer cells. We identified T172 phosphorylation of CDK4 rather than cyclin D accumulation as...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Colleoni, B, Paternot, S, Pita, J M, Bisteau, X, Coulonval, K, Davis, R J, Raspé, E, Roger, P P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537611/
https://ncbi.nlm.nih.gov/pubmed/28368408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.7
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