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The CDK4/CDK6 inhibitor PD0332991 paradoxically stabilizes activated cyclin D3-CDK4/6 complexes

CDK4 and CDK6 bound to D-type cyclins are master integrators of G1 phase cell cycle regulations by initiating the inactivating phosphorylation of the central oncosuppressor pRb. Because of their frequent deregulation in cancer, cyclin D-CDK4/6 complexes are emerging as especially promising therapeut...

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Publicat a:Cell Cycle
Autors principals: Paternot, Sabine, Colleoni, Bianca, Bisteau, Xavier, Roger, Pierre P
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615110/
https://ncbi.nlm.nih.gov/pubmed/25486476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.946841
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