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The CDK4/CDK6 inhibitor PD0332991 paradoxically stabilizes activated cyclin D3-CDK4/6 complexes

CDK4 and CDK6 bound to D-type cyclins are master integrators of G1 phase cell cycle regulations by initiating the inactivating phosphorylation of the central oncosuppressor pRb. Because of their frequent deregulation in cancer, cyclin D-CDK4/6 complexes are emerging as especially promising therapeut...

詳細記述

保存先:
書誌詳細
出版年:Cell Cycle
主要な著者: Paternot, Sabine, Colleoni, Bianca, Bisteau, Xavier, Roger, Pierre P
フォーマット: Artigo
言語:Inglês
出版事項: Taylor & Francis 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615110/
https://ncbi.nlm.nih.gov/pubmed/25486476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.946841
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