Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum

Feeding LDL receptor (LDLR)-null mice a Western diet (WD) increased the expression of IFN-β in jejunum as determined by quantitative RT-PCR (RT-qPCR), immunohistochemistry (IHC), and ELISA (all P < 0.0001). WD also increased the expression of cholesterol 25-hydroxylase (CH25H) as measured by RT-q...

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Veröffentlicht in:J Lipid Res
Hauptverfasser: Mukherjee, Pallavi, Hough, Greg, Chattopadhyay, Arnab, Navab, Mohamad, Fogelman, Hannah R., Meriwether, David, Williams, Kevin, Bensinger, Steven, Moller, Travis, Faull, Kym F., Lusis, Aldons J., Iruela-Arispe, M. Luisa, Bostrom, Kristina I., Tontonoz, Peter, Reddy, Srinivasa T., Fogelman, Alan M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538285/
https://ncbi.nlm.nih.gov/pubmed/28592401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M076554
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