Role of enterocyte stearoyl-Co-A desaturase-1 in LDLR-null mice

After crossing floxed stearoyl-CoA desaturase-1 (Scd1(fl/fl)) mice with LDL receptor-null (ldlr(−/−)) mice, and then Villin Cre (VilCre) mice, enterocyte Scd1 expression in Scd1(fl/fl)/ldlr(−/−)/VilCre mice was reduced 70%. On Western diet (WD), Scd1(fl/fl)/ldlr(−/−) mice gained more weight than Scd...

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Veröffentlicht in:J Lipid Res
Hauptverfasser: Mukherjee, Pallavi, Hough, Greg, Chattopadhyay, Arnab, Grijalva, Victor, O’Connor, Ellen Ines, Meriwether, David, Wagner, Alan, Ntambi, James M., Navab, Mohamad, Reddy, Srinivasa T., Fogelman, Alan M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168294/
https://ncbi.nlm.nih.gov/pubmed/30139760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M083527
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