Interleukin33 deficiency causes tau abnormality and neurodegeneration with Alzheimer-like symptoms in aged mice

Late-onset Alzheimer’s disease (AD) remains a medical mystery. Recent studies have linked it to impaired repair of aged neurons. Potential involvement of interleukin33 (IL33) in AD has been reported. Here we show that IL33, which was expressed by up to 75% astrocytes in the aged brains, was critical...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Transl Psychiatry
Prif Awduron: Carlock, C, Wu, J, Shim, J, Moreno-Gonzalez, I, Pitcher, M R, Hicks, J, Suzuki, A, Iwata, J, Quevado, J, Lou, Y
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2017
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538122/
https://ncbi.nlm.nih.gov/pubmed/28675392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2017.142
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