Requirement of brain interleukin33 for aquaporin4 expression in astrocytes and glymphatic drainage of abnormal tau

Defective aquaporin4 (AQP4)-mediated glymphatic drainage has been linked to tauopathy and amyloid plaque in Alzheimer’s disease. We now show that brain interleukin33 (IL33) is required for regulation of AQP4 expression in astrocytes, especially those at neuron-facing membrane domain (n-AQP4). First,...

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Detalhes bibliográficos
Publicado no:Mol Psychiatry
Main Authors: Wu, Jean, Carlock, Colin, Shim, Junbo, Moreno-Gonzalez, Ines, Glass, William, Ross, April, Barichello, Tatiana, Quevedo, Joao, Lou, Yahuan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8273186/
https://ncbi.nlm.nih.gov/pubmed/33432186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-020-00992-0
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