Post-translational regulation contributes to the loss of LKB1 expression through SIRT1 deacetylase in osteosarcomas

BACKGROUND: The most prevalent form of bone cancer is osteosarcoma (OS), which is associated with poor prognosis in case of metastases formation. Mice harbouring liver kinase B1 (LKB1(+/−)) develop osteoblastoma-like tumours. Therefore, we asked whether loss of LKB1 gene has a role in the pathogenes...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Presneau, Nadège, Duhamel, Laure Alice, Ye, Hongtao, Tirabosco, Roberto, Flanagan, Adrienne M, Eskandarpour, Malihe
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537492/
https://ncbi.nlm.nih.gov/pubmed/28632727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.174
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