SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress

Sirtuin1 (SIRT1) deacetylase levels are decreased in chronic inflammatory conditions and aging where oxidative stress occurs. We determined the mechanism of SIRT1 redox post-translational modifications leading to its degradation. Human lung epithelial cells exposed to hydrogen peroxide (150–250 μM),...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Caito, Samuel, Rajendrasozhan, Saravanan, Cook, Suzanne, Chung, Sangwoon, Yao, Hongwei, Friedman, Alan E., Brookes, Paul S., Rahman, Irfan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Federation of American Societies for Experimental Biology 2010
Pynciau:
Research Communications
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923349/
https://ncbi.nlm.nih.gov/pubmed/20385619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-151308
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