SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress

Sirtuin1 (SIRT1) deacetylase levels are decreased in chronic inflammatory conditions and aging where oxidative stress occurs. We determined the mechanism of SIRT1 redox post-translational modifications leading to its degradation. Human lung epithelial cells exposed to hydrogen peroxide (150–250 μM),...

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Detaylı Bibliyografya
Asıl Yazarlar: Caito, Samuel, Rajendrasozhan, Saravanan, Cook, Suzanne, Chung, Sangwoon, Yao, Hongwei, Friedman, Alan E., Brookes, Paul S., Rahman, Irfan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Federation of American Societies for Experimental Biology 2010
Konular:
Research Communications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923349/
https://ncbi.nlm.nih.gov/pubmed/20385619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-151308
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